Category Archives: Amphetamine Dependency
Amphetamine dependence refers to a state of dependence on a drug in the amphetamine class.
Tolerance is developed rapidly in amphetamine abuse, thereby the amount of the drug that is needed to satisfy the addiction needs to be increased at regular intervals.
Conversely, some researchers have reported observing the opposite effect in animal models: repeated amphetamine use can produce reverse tolerance or sensitization to the psychological or locomotor-stimulating effects of the drug. Development of sensitization to amphetamine may depend on the daily dosage of amphetamine or the amount of time elapsed since the discontinuation of repeated dosing.
In rodent studies, repeated amphetamine treatment produces robust behavioral sensitization (or reverse tolerance) to some of the drug’s effects. Depending on the dosing regimen, sensitization may persist for up to one year after the discontinuation of amphetamine treatment in rodents.
In humans, however, there is no systematic evidence of the development of behavioral sensitization to amphetamine after acute or chronic amphetamine treatment when the drug is used in the therapeutic dose range (i.e., is not abused). The absence of observed sensitization development in humans (compared to that observed in rodents) may be explained by different amphetamine metabolism or different mechanisms of action of amphetamine in humans versus rats.
Amphetamine has the potential to cause physical dependence and withdrawal can be hard for a user.
Self-directed Management of Amphetamine withdrawal amongst recreational users tends to be quite precarious due to lack of proper medical education and prescribing discipline; examples include users who attempt to postpone the amphetamine “crash” by taking more of the drug, which in fact makes matters worse by making the crash even greater. Users may self-medicate using Anxiolytic (Sedating) medicines to allow themselves to sleep or relax, of which may include sedating anti-histamines (cyproheptadine), benzodiazepines (alprazolam) or opioid medicines (Codeine, oxycodone)
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